Abstract Neuroblastoma is a devastating childhood cancer that is vaguely understood and is an aggressive and possibly fatal disease. With children constantly being diagnosed and with no current cure, a greater need for understanding this cancer and other childhood cancers is necessary. This experiment used the cell line SKNSH to model experimentation of the functional and morphological changes of a neuroblastoma cancer cell when treated with all-trans-retinoic acid. The cells were grown in culture and data was collected on morphology, electrophysiology, and protein composition. Through cell passaging, staining, and conductivity tests, results indicated cells that underwent treatment with retinoic acid saw a distinct morphological and functional change compared to the untreated control SKNSH cells. With the data, it was concluded that the treated cells developed a more neuronal like morphological and functional state than their untreated counterparts. This research has implication that provide building blocks to future childhood cancer research.